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The Casebook

Plagues & Cures

History's deadliest outbreaks and the medicine that answered them

9 case histories
The Great Plague of London: The Last Great Outbreak and the Year Pepys Watched a City Empty

The Great Plague of London: The Last Great Outbreak and the Year Pepys Watched a City Empty

The Great Plague of London killed tens of thousands in 1665. Here is what Londoners believed caused it, what the doctors tried, and who they blamed.

Jul 13, 2026Read the case
The Ice Pick Lobotomy: Walter Freeman's Ten Minute Cure for the Mind

The Ice Pick Lobotomy: Walter Freeman's Ten Minute Cure for the Mind

Walter Freeman toured America performing transorbital lobotomies through the eye socket in about ten minutes, sometimes with no surgeon present at all.

Jul 10, 2026Read the case
Victorian Arsenic Cosmetics: How Wafers and Belladonna Drops Poisoned Women for Beauty

Victorian Arsenic Cosmetics: How Wafers and Belladonna Drops Poisoned Women for Beauty

Victorian arsenic cosmetics promised pale, translucent skin and wide, dark eyes. Here is what wafers and belladonna drops actually did, and who got blamed.

Jul 6, 2026Read the case
Black Death Florence 1348: How a City of 100,000 Buried Half Its People

Black Death Florence 1348: How a City of 100,000 Buried Half Its People

The Black Death Florence suffered in 1348 killed roughly half the city. Boccaccio watched it happen, then turned the horror into the Decameron.

Jul 4, 2026Read the case
Bleeding the Patient: Two Thousand Years of Bloodletting and the Four Humors

Bleeding the Patient: Two Thousand Years of Bloodletting and the Four Humors

Bloodletting history's most famous case: George Washington's doctors bled him four times in his final hours, following centuries of medical theory on the four humors.

Jul 4, 2026Read the case
John Snow and the Broad Street Pump: The Map That Ended a Cholera Epidemic

John Snow and the Broad Street Pump: The Map That Ended a Cholera Epidemic

In 1854 Soho, a doctor ignored miasma theory, mapped cholera deaths by hand, and traced an epidemic to one water pump. Epidemiology was born.

Jul 4, 2026Read the case
Inside the Plague Doctor Costume: Why 17th Century Physicians Wore Bird Masks

Inside the Plague Doctor Costume: Why 17th Century Physicians Wore Bird Masks

A French court physician's fix for 'miasma' produced the plague doctor costume: the beaked mask, waxed coat, and cane behind medicine's most iconic image.

Jul 4, 2026Read the case
The Radium Girls: The Factory Workers Who Glowed in the Dark and Paid for It

The Radium Girls: The Factory Workers Who Glowed in the Dark and Paid for It

The Radium Girls hand-painted radium onto watch dials, pointing their brushes with their lips. Their employer knew the danger and let them die anyway.

Jul 4, 2026Read the case
Philadelphia 1918 Flu: The Parade That Killed a City

Philadelphia 1918 Flu: The Parade That Killed a City

The Philadelphia 1918 flu catastrophe began when the city marched 200,000 people down Broad Street against warnings, becoming one of the deadliest cities of the pandemic.

Jul 4, 2026Read the case